Modeling Development, Homeostasis and Disease of Tissues Using Cellular Potts Model (CPM)

Wednesday, June 17th 2014 , 11:40 - 13:00

ECMTB 2014 Goetheborg, Sweden. Exact Location: To Be Announced

Location : Pascal Auditorium ,Hörsalsvägen 1 Goethenburg, Sweden, (building next to the library at Chalmers University)

See the link for directions/map Pascal Auditorium

Building a functional simulation of tissue, organ or even an entire organism requires an unprecedented effort to fuse techniques derived from biology, chemistry, physics, computer science and information science. After decades of method development several modeling techniques emerged and currently most tissue modeling is done with Cellular Potts Model (CPM), Center Models, Finite Element techniques and generic rule-based agent models. Ideally all of these methods should be interchangeable and be able to give similar predictions. In practice cross-method validation still remains an item on a wish list. The situation is somewhat better for Cellular Potts Model. There exist several packages (CompuCell3D, Tissue Simulation Toolkit, Morpheus, Chaste, Simmune) implementing this model which makes model validation somewhat easier- albeit only within CPM framework. CPM method represents cells as spatially extended objects, allows realtively easy modeling of cell-cell adhesion, cell polarization, cell shape changes etc... and most importantly it can run simulations with more than 1 million of cells on a single CPU within reasonable time. The availability of ready-to-use software packages made CPM one of the most widely used modeling technique for tissue modleing.

Up-to-date researchers world-wide used CPM to model biological phenomena/organisms such as: tumor growth, gastrulation, skin pigmentation, neurospheres, angiogenesis, immune system response, yeast colony growth, Myxobacteria, stem cell differentiation, Dictyostelium discoideum, simulated evolution, general developmental patterning, convergent extension epidermal formation, hydra regeneration, plant growth, retinal patterning, wound healing, biofilms, limb bud development, liver toxicity, somite formation, age related macular degeneration etc...

Purpose: The proposed mini-symposium will focus on overviewing latest advances of CPM modeling. We will also examine possibilities to advance existing CPM-based models, improve reuse of third-party tools in CPM modeling frameworks, merge CPM with other modeling techniques such as continuum methods or center models. Additionally we will encourage speakers to present challenging modeling problems which can be addressed by CPM or related modeling techniques. The minisymposium will allow conference attendees to get fairly thourough overview of recent advances of one of the main-stream modeling techniques used in contemporary methematical biology.




Wednesday, June 18th , 2014 11.40-13.20

11.40 - 12.00

Sonja Boas

Synergy of vacuolation and cell-cell repulsion in lumen formation

12.00 - 12.20

Marco Scianna

Cellular Potts Models for Cell Migration

12.20 - 12.40

Gibin Powathil

Multiscale techniques in cancer modelling and treatment prediction: A Compucell3D approach

12.40 - 13.00

Walter de Back

Measuring and modeling dynamics of VEGF retention in vascular patterning

13.00 - 13.20

Stan Maree

The Cellular Potts Model in the context of Cell Surface Mechanics

GoetheborgCPMSymposium_2014 (last edited 2014-06-17 16:35:59 by mswat)